>>>I would like to reassign CD/DVD drive to a different letter. Currently I have on this notebook drive C: (hard disk) and D:(CD/DVD).
>>>
>>>I want the CD/DVD to be drive E: and map a folder on the C: drive to letter D:
>>
>>For a folder, try DOS SUBST command

SUBST D: C:\myfolder

>
>Thank you for the suggestion on mapping a folder on the C: drive.
>
>My concern right now is if I change the letter assigned to the CD/DVD that something may stop working. Actually this is the warning the Windows shows when you try to reassign the letter. I wonder if Roxio (the software that uses the CD/DVD) will have a problem with this change.

No, it will find CD/DVD no metter what letter you use.