>I have not had big problems with programs stomping each other from MS-Dos through Win31, NT, W98, W2K up to XP - anything special to watch out for in Vista ? Currently my C: disk is only used for the boot manager...

I've had linux and Windows XP stomp on each other before. As well Windows 2000 server overwrites the MBR of anything else if you try to do a multi-boot.