Greetings Kevin,

I've been doing some more troubleshooting regarding AJAX working intermittently with the use of an UpdatePanel and an ObjectDataSource and these are the results I'm seeing. Can you let me know if you see the same results?

Created a MM.Net Web Form Page with Master Page.
Added Script Manager
Added UpdatePanel (UpdateMode = Always)

Scenario 1:

added mmButton to UpdatePanel
added mmLabel to UpdatePanel
added method ShowTime to update Label with DateTime.Now.ToString()
added click handler for button that calls ShowTime

Observed: Expected functionality

Scenario 2:

Added mmDropDownList outside of UpdatePanel (AutoPostBack = true)
Configured ObjectDataSource for drop-down calling MM.Net Business Object Patient.GetAllEntities
Set Display and Value properties via ObjectDataSource Wizard
added SelectedIndexChanged handler that calls ShowTime
added Trigger in UpdatePanel for SelectedIndexChanged

Observed: Intermittent updating of label

Scenario 3:
Removed ObjectDataSource
programmatically added two items to drop-down list in Page_Load

Observed:Expected funcionality

Scenario 4:
Added SqlDataSource to page
Bound mmDropDownList to SqlDataDource

Observed:Expected funcionality