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>>Walter, your argument is tantamount to saying you will not use a condom with a stranger becuase it gives a false sense of security. Your partner may or may not have an infection but not wearing a condom with a stranger is irresponsible. AV software is the same. It will provide protection for a wide array of known malware and some unknown. Just becuase it is not 100% effective and cannot necessarily prevent unknown attack vectors does not mean that you should not use one. If you do not employ basic security measures then you become part of the problem instead of the solution.
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>Or you could say that his argument is the same as saying he will not carry around a condom because he isn't planning on having relationships with random people. If he is having relationships with one trusted person (or multiple trusted people if he is a playa) then he doesn't feel the need.

Yes but if his computer is connected to the Internet then he is, by definition, a "playa" with unknown partners.