Check Skype4COM at https://developer.skype.com/Docs/Skype4COM. There's a VBS sample code to make a call at https://developer.skype.com/Docs/Skype4COMLib/Call_vbs.

>just wondering if anyone has linked into skype from an application. I would like to add a button to one of our applications that starts a skype call.
>~M