>>Have you tried booting into safe mode first? If that does not work then you might need to put this drive as a slave drive to a clean machine and clean the infected drive from the clean machine (or just salavge what data/docs need to be saved and then wipe the hard disk and do a clean O/S reinstall).
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>What should I do after we booted this laptop in the safe mode?
Then try and install / run AV and othr maware removal tools. Safe mode may prevent some malware from being (fully) active and hence give the removal tools a better chance.
In the End, we will remember not the words of our enemies, but the silence of our friends - Martin Luther King, Jr.
