>>In addition to all the other suggestions of cleaning out temp folders and cleaning out other junk -- make sure you've got an anti-virus as well as anti-spyware software (also it's a good practice to verify that it's running and up to date as well).
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>Good point in general, but ironically, antivirus and antispyware that is functioning perfectly can significantly show a machine :-(

True, but I'd rather have the performance degradation from an antivirus over one from spyware/viruses. Although I am indeed careful, there is the possibility that I might slip up -- always nice to have a safety net. It's especially important to have some sort of antivirus in place when dealing with computers in a network.