Works for me. What is different in your case?

CLEAR
PUBLIC loXMLDoc AS Msxml2.DOMDocument.4.0

TEXT TO lcXml NOSHOW
<names>
   <name>Alice</name>
   <name>Bert</name>
   <name>Charlie</name>
   <name>Diane</name>
   <name>Eric</name>
</names>
ENDTEXT
lcXmlFIle = FULLPATH("names.xml")
lcNewXmlFile = FULLPATH("names2.xml")

ERASE (lcXmlFIle) 
ERASE (lcNewXmlFile)

STRTOFILE(lcXml, lcXmlFIle) 

loXMLDoc = CREATEOBJECT("Msxml2.DOMDocument.4.0")
loXMLDoc.async = .F.
loXMLDoc.load("names.xml")

loRoot = loXMLDoc.documentElement

loChild = loRoot.childNodes.item(2)
loExNode = loRoot.removeChild(loChild)

loNodeList = loXMLDoc.getElementsByTagName("name")
FOR EACH loElem IN loNodeList
   ? loElem.firstChild.nodeValue
ENDFOR

loXMLDoc.Save(lcNewXmlFile)

MODIFY FILE (lcNewXmlFile)

>
>I am using the ms xmldom utility to create and manipulate xml data. It's works great. What I am having trouble with right now is removechild().
>
>If I want to delete a node completely loRoot.RemoveChild(oChildNode) works in that i can check the node count and it has successfully reduced by 1. However when I finally save() the contents of the whole object to file, the deleted node is still present!
>
>What am missing? If I change existing attribute values and save the changes persist.
>
>Any help will be much appreciated