You sure the image file isn't flagged as read-only??

>I can no longer manipulate images in Photoshop. I do not know what happened. No matter what image I am opening, and even if I restart Photoshop, no matter on which options I am clicking on, as soon as I move the mouse over the image, I cannot see the cursor represented by the option I clicked. The only thing I see if a hand. I cannot change anything in the image, cannot resize it, cannot change the text and so on. Anyone would know what could have caused this?