<Grid> <FlowDocumentReader IsHitTestVisible="False"> <FlowDocument> <Paragraph>Name:<Run FontSize="44">Itzhak Perlman</Run></Paragraph> </FlowDocument> </FlowDocumentReader> </Grid>Edit: That's probably not how your going to want to do it in your app. But that is a way to get WPF to do the alignment work for you.
<StackPanel Orientation="Horizontal"> <Label Margin="0,33,0,0" Content="Name:"/> <Label Content="Itzhak Perlman" FontSize="44"/> </StackPanel>