The UPDATE STATISTICS with FULLSCAN is more accurate but can cause blocking

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>A simple question for the SQL Server experts: Forgetting about the time it takes to update, is there any disadvantage to doing a FULLSCAN when updating statistics? Asked from the flip side: Is there any advantage to using a sampling rate rather than doing a FULLSCAN when updating statistics.
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>Again, please do not consider the time it take to run... assume we have an unlimited amount of time for database maintenance jobs.
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>TIA