Not sure how helpful, but take a look at this thread http://social.msdn.microsoft.com/Forums/en-US/transactsql/thread/b095b8f5-9075-46c8-b28e-0509708fa972



>Kevin,
>
>
>Beginners question...
>
>
>Are there any serious drawbacks to using a guid as a pk that you know of ?
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>While we may get away with an int for most tables, there's one that may grow very large - if the business is successful
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>I am thinking of making the pk of all tables guid
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>I also want to add the possibility that someone can store a subset of the database onto his laptop, work on it, and later sync it back to the db
>
>Your opinion ?