>I have a DropDownList on my page. Loading it like this:
>
>

>cboProgramManager.DataSource = dsProgMgr.Tables[0];
>cboProgramManager.DataTextField = "Program Manager";
>cboProgramManager.DataValueField = "Program Manager";
>cboProgramManager.DataBind();
>cboProgramManager.SelectedIndex = -1;
>

>
>When I run it the first item in the list is selected. I don't want any item selected by default.

From help:
Use the SelectedIndex property to programmatically specify or determine the index of the selected item from the DropDownList control. An item is always selected in the DropDownList control.
(my emphasis)
One solution is to add a dummy entry at the top:

cboProgramManager.DataBind();
cboProgramManager.Items.Insert(0,new ListItem("Select...."));

so that a SelectedIndex of 0 means nothing chosen....