I can't give you specifics as I've never worked with Mono. The biggest issue, IMO, is UI differences. You simply can't create a single app and then just run/recompile it for the other platform.

>Quick question, how "easy or transparent" for a NET app to run with Mono on the Mac or Linux. Any thoughts are appreciated.
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>I am searching out the best cross platform possibilites (there are not many) at this point.
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>Any thoughts are appreciated, and even additioinal suggestions for this. I am already casually familiar with Omnis, 4D, and also RealBasic/RealStudio (all three of these box you in as they niche products which I not excited about).