I am using this for a StrTran() function followed by a similar function but in case insensitivity:

        ' Equivalent of VFP StrTran()
        ' expC1 String
        ' expC2 Search for specific character
        ' expC3 Replace
        Public Function StrTran(ByVal tcSearchIn As String, ByVal tcSearchFor As String, _
         ByVal tcReplace As String) As String
            Dim loStringBuilder As StringBuilder = New StringBuilder(tcSearchIn)
            Return loStringBuilder.Replace(tcSearchFor, tcReplace).ToString()
        End Function

        ' Equivalent of VFP StrTran() with case insensitive
        ' expC1 String
        ' expC2 Search for specific character
        ' expC3 Replace
        Public Function StrTranCaseInsensitive(ByVal tcSearchIn As String, ByVal tcSearchFor As String, _
         ByVal tcReplace As String) As String
            Dim lnLength As Integer = tcSearchIn.Length
            Dim lnLengthSearchFor As Integer = tcSearchFor.Length
            Dim lnLocation As Integer = 0
            Dim loStringBuilder As New StringBuilder(lnLength)

            ' Check inputs
            If lnLength = 0 Or lnLengthSearchFor = 0 Or lnLengthSearchFor > lnLength Then
                Return tcSearchIn
            End If

            While lnLocation + lnLengthSearchFor <= lnLength

                If String.Compare(tcSearchIn, lnLocation, tcSearchFor, 0, lnLengthSearchFor, True) = 0 Then

                    ' Add the replaced string
                    loStringBuilder.Append(tcReplace)

                    lnLocation = lnLocation + lnLengthSearchFor
                Else

                    ' Advance one character
                    loStringBuilder.Append(tcSearchIn, lnLocation, 1)
                    lnLocation = lnLocation + 1

                End If

            End While

            ' Append remaining characters
            loStringBuilder.Append(tcSearchIn, lnLocation, lnLength - lnLocation)

            Return loStringBuilder.ToString()
        End Function

Would it there be a way to simplify the second method as we did for the first one?