>As above - the Client Profile excludes ASP.NET assemblies - for most WinForm and WPF applications they are not needed.

Most of my classes uses it. So, I have to go with the full framework.

>Did you read the link? You shouldn't need to install the entire Framework. The full runtime assemblies for X86 and X64 are less than 50Mb.

Yes, I just read it. Basically, the way I understand it is that I would be better to include the .NET Framework 4.0 as part of my EXE. So, this will make it like 40 MB but would avoid Setup.exe to freak completely and request 2 GB of free disk space.