John,
That's impossible for me to answer. Only the API docs can tell you what you have to do to get it to work.
If you search the MSKB on "vfoxwin and agent" you'll find an article of using VFP to use the MS Agent control to speak what's in a textbox on a form.
> I meant before issue the command object.speak("Welcome"), should i initialise something like enginefeature, gender to make the program able to speech??? I try to do the command below but it is not working.
> object.speak("Welcome")
> This is the only statement in the command button. I add the ActiveX control on th form already.