Perhaps they reconfigured something on the E-mail server? One common anti-spam strategy is to close TCP port 25. You could do the following:
* Use ping and see if you're able to establish contact with server (though sometimes ping will fail due to how they've got firewalls configured). If you get a response, you know there is something there listening (as a mentioned earlier, failure doesn't mean that there isn't anything listening).
* Use telnet to see if you can establish a connection -- use TCP port 25. If it succeeds you should see a "banner" with which the E-mail server will identify itself. If you get "connection refused" then they've likely closed that port and you'll have to find out what alternate port they've configured.

>I am using Sergey's CDO 2000 email class.
>
>It's been working great.
>
>Friday, one of the user's had trouble sending out a proposal.
>I tested it on my machine and had the same problem.
>
>From within my Vfp application, I create a pdf package and email it.
>The email failed with the following error:
>
>1 ERROR: :1429 # send # 146
>The message could not be sent to the smtp server.
>The server response was not available.
>
>Do you know what the problem is?
>
>From what I've been told, the smtp server name, userid and password have not changed.
>Do I need to verify this?
>If so, how?
>
>Any help would be greatly appreciated.
>
>I'm using cdo2000.prg from 12/14/2009.
>
>Thanks,
>Deb