We are looking at the Office 2010 security settings now. Thanks for your help!

>Somethings did change in Office 2010 that could be causing the issue. You should consult MSDN or the Office development forums that Microsoft hosts.
>
>>An excellent idea, but the program already uses the path from the PC point of view. The user having the problem is also running Office 2010 - I am wondering if there is a security setting in Office that is preventing the program from updating and saving the spreadsheet (?).