MS is realizing Node is one of the things to look out for - Scott H. blogs about it and Webmatrix.

http://www.hanselman.com/blog/WebMatrixAndNodejsTheEasiestWayToGetStartedWithNodeOnWindows.aspx

Yes, JS is not as clean as Python (and we know that sometimes the ability to get down and dirty is not always negative),
but a JS client / JS backend can miss out some of the pyjamas brittlenes visible on the pyjamas list,
or other translations from various laguages moving data via JSON and partially duplicating validating code.

I don't understand/have a frame of reference for even half of the points argued on the node list,
but still think it is wise to at least scan. Currently I see either a Node/Js based or a Python fwk as my future.