>I have been having a problem with new installation of an existing ASP.NET application on Windows 2008 R2, IIS. (Note that the same application runs well on some other customers' Windows 2008, IIS). The problem we are getting when running any .ASPX page (even simple Hello World) is:
>
>

>: HTTP 404. The resource you are looking for (or one of its dependencies) could have been removed, had its name 
>changed, or is temporarily unavailable.  Please review the following URL and make sure that it is spelled correctly. 
>

>
>We (I and the customer web admin) looked at all kinds of possible settings but can't seem to find a solution. Any setting you recommend we should look at?

This is an upcoming setup I will have to support. So, I am interesting in what is causing that. Can you try with a simple Test.html page. This will bypass the .NET layer and will tell you is this is related to .NET or not.