>Eventually, more powerful simulations will be able to model on the scale
>of a molecule, then a cell and even a human being."
>
>It occurs to me, that if this were to become a reality, there is the question,
>what does the simulated human being know about its world?

He makes a lot of assumptions.

>How does our "God's Eye" view of the simulation compare to the view of
>the simulation's internal observer?
>Any predictions?

A movie dealt with this ... The Thirteenth Floor. To the "units" operating inside the machine, to them it was real. :-)