The most profound medical discoveries of my time were penicillin and the Salk vaccine, neither of which came from big pharma.

During the 60's cortisone was heralded as a miraculous cure for arthritis and now it's rarely prescribed and in some cases its use is prohibited.

In fact, many of the "blockbuster" drugs have been shown to be relatively useless, or in the case of Celebrex mortally harmful.

I've had several "small" pharma clients and I've seen that there are a lot of people working diligently, but they're making huge, huge paydays while doing it.
Some of the margins are obscene.

The myth that the high prices fund research is convenient, but it's just that.. a myth.
They fund political influence, huge estates and other toys for the principal owners.



>>>OTOH you have doctors getting kickbacks from pharma corporations in various ways - which often leads to more expensive medicines being prescribed when functionally equivalent alternatives exist.
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>That's often stated, but when you do a study, this is more common: http://uanews.org/story/study-doctors-wary-research-funded-pharmaceutical-industry ... it seems many doctors adopt a "I don't believe you even if you're telling the truth" attitude toward big pharma, not the cozy favoritism some people like to imagine. ;-) If you'd used orthopedic surgeons choosing very expensive implants it would be more true since industry definitely does woo the surgeons, but these days even surgeons are banding together to set regional policies based on efficacy and price.
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>>>Also the practice of changing recipes ever so slightlty just when the end of patent time comes near to keep users accustomed to the brand name with the product instead of switching to then possible generica... Bigger bucks often corrupt more.
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>Maybe you won't need to worry much longer as this becomes more common: http://seekingalpha.com/article/847111-eli-lilly-new-drug-nightmares-will-sink-stock-in-2013 ... if it's more profitable to compete in generic markets or design around blockbuster patents, companies won't want to do the research and there won't be blockbuster drugs to worry about. We need to be careful what we wish for. It's like doctors- beware the poor doctor! Also beware increasing the risks of research if you want to see cures for new diseases in our lifetimes. FWIW India and Australia both have initiatives underway to limit patents while NZ has a Pharmac agency tasked with bargaining with pharmaceutical companies for the best deals. Maybe should be grateful for the US since their comparatively astronomical prices are enough to pay for a lot of research.