>I usually have my Display Settings at 1024 by 768.
>However, is there a way to change the display settings at run-time to 800 by 600?
>
>I need to do that in an app (if possible) for a hard-to-see person.
>
As Hilmar said, generally, it's a bad idea to change the screen resolution. What you should focus on is making your application look good, whatever the user's chosen resolution is.
This paper includes code for adjusting the font size based on the form size. You might be able to adapt that idea:
http://www.tomorrowssolutionsllc.com/Conference%20Sessions/Developing%20Applications%20For%20Everyone.pdfTamar
P.S. Is that "hard-to-see person" a Who? They're hard to see. <g>