I removed the following two files from the Web site Bin directory:

Interop.ADODB.dll
Interop.CDO.dll

...so I can run the Web site application pool in 64 bits.

I would have assumed that a specific page on the Web site would no longer work as it has lines like this:

        Dim loStream As ADODB.Stream = New ADODB.Stream

        loStream.Mode = ADODB.ConnectModeEnum.adModeReadWrite
        loStream.Type = ADODB.StreamTypeEnum.adTypeText
        loStream.Open()

        loStream.LoadFromFile(cFile)

        oMessage.DataSource.OpenObject(loStream, "_Stream")

        ' From
        If Not RetrieveHeader(oMessage.From) Then
            Return False
        End If

        cFrom = oMessage.From
        cFromAddress = cAddress
        cFromName = cName

So, if the two 32 bit library files required for ADODB related commands to work are no longer in the Bin directory, how can this work? I did stop and start the Web site a few times.