Here is what I added in the Application_Start() to take care of it. I cannot see a reload of the worker process instances on UAT after many tests I have did. I am not able to deploy that on a production environment soon however. However, I will see if I can have that support inside the global.asax instead as a temporary measure.

    Sub Application_Start()
        Dim loFieldInfo As FieldInfo = Nothing
        Dim loMethodInfo As MethodInfo = Nothing
        Dim loObject As Object = Nothing
        Dim loObject2 As Object = Nothing
        Dim loPropertyInfo As PropertyInfo = Nothing

        RegisterSoapExtension(GetType(TraceExtension), 1, 0)

        ' Microsoft IIS/ASP.NET has a bug that after a very long period of time, it can start restarting the worker process
        ' several times per minute, for days, causing an enormous amount of load
        ' As there is no guarantee this will come back, we disable this FCN at this level
        ' This code will turn off monitoring from the root website directory, but monitoring of Bin, App_Themes and other folders will
        ' still be operational, so updated DLLs will still auto deploy
        loPropertyInfo = GetType(System.Web.HttpRuntime).GetProperty("FileChangesMonitor", _
         BindingFlags.NonPublic Or BindingFlags.Public Or BindingFlags.Static)
        loObject = loPropertyInfo.GetValue(Nothing, Nothing)

        ' Turn off FCN on the sub directories
        loFieldInfo = loObject.GetType().GetField("_dirMonSubdirs", BindingFlags.Instance Or BindingFlags.NonPublic Or BindingFlags.IgnoreCase)
        loObject2 = loFieldInfo.GetValue(loObject)

        ' Send the deactivation notice
        loMethodInfo = loObject2.GetType().GetMethod("StopMonitoring", BindingFlags.Instance Or BindingFlags.NonPublic)
        loMethodInfo.Invoke(loObject2, New Object() {})

    End Sub