>>Odd. Does F6 work ?
>
>F6 does not work. I have not seen any indication that F6 was able to compile. Are you using that?

F6 is standard as an alternative to Ctrl+Shift+B in C# . Not sure it's the same in VB..
You can check them by looking in Options/Environment/Keyboard.

Anything in the Output window when you use Ctrl+Shift+B ?