>>Why do you need to cast to nvarchar(max) and not varchar(max)? Are you using unicode? Also, why do you need to cast back to ntext? I don't think you need to cast back and it should work fine.
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>The syntax was targeting a memo field. This is why a direct REPLACE() cannot be used.
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>As far as replacing content from a memo field, if you have a simplest way to achieve that, I will look at it.

What is the type of the Subject_E column in SQL Server and what is the collation of this column?