>Under Windows 10, what are you mostly using to optimize disk performance. Before, we use to align the sectors with built-in tools and things like that. Anything specific we should consider for Windows 10?

If you use an SSD (solid state drive) it won't really matter any longer. SSD's are much faster than hard drives, and do not suffer as noticeable performance degradation from file fragmentation.

In addition, by default Windows uses Superfetch, which is a program designed to monitor what is used most often and keep those files in an optimum position for you, even pre-loading them into memory, so even if your drive is largely fragmented, the things used most often won't see any noticeable degradation in performance because of it.