>>>My POV is to doubt all vaccines until at least 2 months are gone (counted after 2. shot on double dosed vaccines) after at least 10 million people are vaccinated and then temper that doubt with own estimate of current risk vaccine should protect against.
>>>
>>>As we go into summer, I am at the moment reluctant to take vector vaccines if offered. We over here are neither given choice on vaccine or time, EU bickering on price (and thereby priority and delivery) has put us in Socialist and bureocratic dream world., Still waiting to be offered Pfizer/Moderna, turned down "offered" AZ, while our politicians already are planning to send out 100 million doses to Japan for Olympic Games and more later to poor countries.
>>>
>>>Big question might be if I am not offered one of Pfizer/Moderna until August and then might be offered choice between vector vaccine or freshly certified CureVac : also mRNA, but not having track record of many millions.
>>>
>>>this gambler is betting €22 (has given a bit of thought to it...)
>>>thomas
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>>That is older vaccines. You really need to understand mRNA.
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>I think my understanding is a bit above "interested layman", but I cannot discuss differences between vector and mRNA on produced and residual protein and peptide level.
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>But this is irrelevant to my argument, as "large number" stabilizes estimates of gained protection ("immunity"), which when calculated from a 30-50K pool with low 3 figure total infection count cannot be depended on as much as figures gained after a few million doses.
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>Yes, side effects like the blood clotting in vector vaccs and perhaps myocarditis with Pfizer/Biontech will also surface only with million doses - but my main angle to decide when and what to vacc is NOT the risk of side effects. I am quit aware on differences of 1 or 2 digit deaths per million on vaccines vs. 90000 on 3.7 million verified infections, so probably 15 million infections not tested or verified, resulting in >4500 deaths per estimated million infections or 0.45% case fatality est.by total infections or 2.47% case fatality of verified infections.
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>My calculation is wait 2 or 3 months in summer (low risc time) to get twice the protection protection for 6- 9 months of colder weather, which is high risc time.
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>>Once again, my opinion on this is going to be poo-pooed by peanut gallery. I worked for a world famous medical professor of microbiology. He and his wife were both heads of their departments and urged me to go into medicine. When your immune system encounters a live vaccine, it samples it and begins to build defenses. That is a live virus. A traditional vaccine gives you either live or weakened or dead actual virus. mRNA gives you a small piece of the virus.
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>IIRC mRNA will cause cells to *produce* small virus parts, similar to the DNA carried by vector virus (Ape-Adeno in AZ case) into the muscle cells near vaccine injection point. Immune system learns to defend against spikes *produced* by muscle cells, but *NOT* against the mRNA or DNA info string encased in lipids or virus. Production of spikes/spike parts will cease after 5-8 days. Those vaccine produced spikes or spike parts already seem to be a danger to ***some*** body systems, for instance causing *sometimes* blood clotting, although this by far less a danger compared to the "active" spikes on live virus produced by a real Corona infection. (JR, correct me if I am off base...)

That is my understanding. I have to keep it simpler for the lay person.

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>>Your immune system can learn from that. You feel a bit crappy after the vaccine because your immune system reacts to everything. It passes in a day or two. I had chickenpox - it was a horrible week. 40 years later this same virus that laid dormant in my body, crawled along my nerves to ignite like fire as shingles. The immune system did not cure it at first. Did not prevent it acting as shingles. I'll take a vaccine any day over that.
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>I will take a vaccine before winter - period.
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>my 0.02€
>thomas