>>>>>A lot of times the user won't be using the mouse but the keyboard to scroll through a combobox list, so click() won't fire.
>>>>
>>>>Use Programmatic/Interactive Change and don't worry about user navigation skills.
>>>
>>>This will not work since the user can simply tab over the field without changing anything. Since no change has occured, the interactive change will not fire.
>>
>>But what's the idea to check if no change happened?
>
>Because the combobox value is initially blank. Once it has focus, the user should not be able to leave it blank.

Ok. There are two things:
1. Combobox is never blank if you initialized it right.
2. I posted already that it's better to collect 'Save' code under 'Save' button. If you want to give a user a hint to enter, you could Setfocus() from Save.Click or just make some Combobox.ToolTipText, use different label, color, etc.
It always depends on personal taste.