>>I have an application that is running on about 50 computers with no problems. I have one user that on his computer an area of the screen does not react to mouse clicks either left or right. There is a shape object in that area the user is supposed to right click. Has any of you had this problem.
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>>TIA
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>What make/model of mouse is being used, and what driver (under what OS)? Is it different from the ones that are working properly?

Exactly, I've seen the same thing with a user that had a new mouse with the wrong driver...