>1-i wanna know how to modify the number of columns and size in labels

In the report designer click on File then page setup. You will see a section on setting the number of columns. The size of the labels is adjusted dragging the the detail band.

>2-I create it a label using the label wizard , and when i choose the font and select "draft" the draft font never fix in it (the font serif it fixed)
>something wrong??

Sorry I don't know the answer to the second part.