This was my first solution. The problem was, I'm also setting DisableBackColor when a cell is disabled for visible feedback and this colors the whole column.

>You can do it in the AFTERROWCOLCHANGE event of the grid.
>

>DO CASE
>CASE record = 1 && sample condition only
>    This.Column3.Enabled = .F.
>    This.Column5.Enabled = .T.
>CASE record = 2
>    This.Column3.Enabled = .T.
>    This.Column5.Enabled = .F.
>OTHERWISE
>    This.Column3.Enabled = .T.
>    This.column5.Enabled = .T.
>ENDCASE
>

It's "my" world.  You're just living in it.