Phil, this is what I use in one of my app's.
Keypress event of the form.

LPARAMETERS nKeyCode, nShiftAltCtrl

IF nShiftAltCtrl = 2 &&-CTRL KEY PRESSED
DO CASE
CASE nKeyCode = 19 &&-CTRL S (SAVE TRANSACTION)
THISFORM.PAGEFRAME1.PAGE1.DBFNAV2.CMDSAVE.SETFOCUS()
KEYBOARD "{spacebar}"

Hope this helps.

Joe