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From what I have read I was under the impression that there wouldn't be any performance increase using INDEXSEEK() over SEEK(). I have a looping counting and totaling procedure where all I did was change a SEEK() to INDEXSEEK() with the move record pointer parameter set to .T., the time the procedure took with the SEEK() was 363 seconds, after changing to INDEXSEEK() the procedure takes 8 seconds. This occurs no matter if I reboot after each run or not, so caching isn't an issue.
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I've run into the same, Greg. It is quicker in nearly every case I have benchmarked. I can't say that I have ever seen differences as extreme as the ones you mention, though.