Yes. You have to work with both the Out of Office Assistant and the Rules Wizard. Here's the help on that (cut and paste from Outlook Help):
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Create a rule with Out of Office Assistant
To create an out of office rule, on the Tools menu, click Out of Office Assistant.

Click Add Rule.

Under When a message arrives that meets the following conditions, specify the conditions of the rule that the message must meet for the action to occur.

Learn about how rules are applied.

To specify that this rule must be the last one applied, select the Do not process subsequent rules check box.
For Help on an option, click Help.

To specify more conditions, click Advanced, select the options you want, and then click OK.

Under Perform these actions, select the options you want. You can select more than one option.
Note If you specify that a message must be deleted, rules that follow the delete rule do not affect the message.


>Does anyone know of a way to set up Outlook to auto reply a certain message once it's received an email in it's inbox?