Yup you can.
I dont know of any good examples, but it is similar (as far as methods etc) to the of VB.

oVSS = createObject("Sourcesafe")

should create the object for you, then using the various methods should work fine.

oVSS.open([srcSafe.ini], [User], [Pass])
item = oVSS.VSSItem([Path])

etc etc

You will probably have to look at VB examples however to get help with what the methods do.