>I have erased the printer definition in Expr, tag, and tag2 (first record in .frx) of about 250 reports, and only added 'ORIENTATION=1' when landscape.
>Problem is, every so often I get errors "1957 Error accessing printer spooler" or "1958 Error loading printer driver" and seems because the user is low in memory, but it started to happen on users with plenty of memory.
>Can I get some insights regarding this issue?, is it OK to clean the fields mentioned above, or am I missing something else.
>Thank you,

You can safely blank out TAG and TAG2 fileds. You've to remove only three printer related lines from EXPR filed

DRIVER=
DEVICE=
OUTPUT=

Don't forget that you've to do report clean up after each report modification. You can automate this process by using projecthooks. See mskb #Q257624 'HOWTO: Clear Report TAG, TAG2, and EXPR Fields Using .pjx Hooks'.