CTRL + F4 = for your forms, set the property Closable=.F.
ALT+F4 = for your App if it runs on VFP main screen _Screen.Closable = .F.
if is a Toplevel Form see answer 1
For CTRL+ALT+SUPR really I don't know
Mauricio
Be fast like the Fox
Be free like the Penguin
Se Rápido como el Zorro
Se libre como el Pingüino