Here is something I use:

Me.BindingContext(DataSet1, "Table1").EndCurrentEdit()

You can test it by putting this code as first row into Timer controls' Tick event. Set Interval of the timer to 5000 and add second row, which reads current record:

MessageBox.Show(CType(Me.BindingContext(DataSet1, "Table1").Current, DataRowView).Row("SomeField").ToString())

If you change content of the control, which is bound to "SomeField" (TextBox, for example), when MessageBox pop-ups, it will show new value.