Donald,

>I am having problems running start-up menu: DO mainmenu.mpr (file not found message).

It sounds like you either haven't regenerated the MPR from the MPX/MPT or it's ended up along a path that's different. Do you see a mainmenu.MPR file in the place where the MPX is?

>I am having problems running Debugger: (Cannot create temporary file message)

It sounds like your Tools/Options/File Locations page needs some setup.