>Why is it that Help is not executed when pressing F1 in 8.0 at runtime? However if the PC have VFP8.0 development installed, it runs well. We are not encountering this in 7.0. Are we missing something?

Check section Applications Using HTML Help in Mike Stewart's Walkthrough: Creating a Visual FoxPro Application Setup Program Using InstallShield Express in VFP8 help or at http://msdn.microsoft.com/library/default.asp?url=/library/en-us/dv_foxhelp/html/fowlkwalkthroughcreatingvisualfoxproapplicationsetupprogramusinginstallshieldexpress.asp