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>Personally, I'd choose locations where many people could get there without having to change planes -- that is, airline hubs.

Las Vegas is ranked in the top 10 non-stop destinations in the US.

>As for hotels, which are actually the more significant expense for most people, I certainly enjoy the amenities of a resort, but don't really get enough time to use them. I have reached the point in my life where I want a certain level of hotel room, but for my family, I certainly price shop.

You can find any level you want in Vegas.