I don't know if anyone can help with this one but......
I've put assemblies into the GAC which should be referenced by a number of web clients existing in a number of virtual directories.
So, to explain further, each UI assembly, existing locally in the virtual directory bin dir references the same GAC component which in turn references a number of other components that also live in the GAC. However when I set this up and I set references to the GAC components in my UI assembly, build and then run, it fails. It's driving my Config Mgr nuts!

Does anyone have any ideas?

Thanks,
James