Did you somehow lose the "handles" clause in the code behind for the click event. e.g.

Submit_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Submit.Click

>I have a server control submit button that doesn't appear to be posting back. I have a break point in the page load of the web form and in debug mode the button does nothing when clicked.
>
>Has anyone seen this? What could cause this?