Yes you can. Here's an example that edits an XML document.
Dim doc
Dim node
Set doc = CreateObject("MSXML2.DOMDocument.3.0")
doc.async = False
doc.Load "c:\books.xml"
If doc.documentElement.hasChildNodes Then
Set node = doc.documentElement.childNodes(0)
Set node = node.selectSingleNode("./price")
MsgBox node.Text
node.Text = "100.00"
MsgBox node.Text
doc.save "c:\books2.xml"
End If
<?xml version='1.0'?>
<bookstore>
<book genre="autobiography" publicationdate="1981" ISBN="1-861003-11-0">
<title>The Autobiography of Benjamin Franklin</title>
<author>
<first-name>Benjamin</first-name>
<last-name>Franklin</last-name>
</author>
<price>8.99</price>
</book>
</bookstore>
