It appears MS is targeting Windows and Mac, thought it's hard to tell if Mac will get the integrated .NET framework and DLR. Maybe the open-source portions will make it to Linux.

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>Yep, it seems the DLR is targeted for cross-platform browsers along with the Silverlight stuff. (Does that mean cross-browsers on Microsoft OS only or really cross-OS -- I've got more reading to do).
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>However, related to the DLR in the browser, I suppose this means that the same plug-in might work in the Browser Control which can be embedded into desktop apps (Rick Strahl has a cool white paper from a while back on embedding ASP.NET in .NET WinForms apps).
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>If it can work in the Browser Control as VBScript and JavaSCript can, this could open some very interesting possibilities.