I seem to remember that at some point, Microsoft removed the need for the Interop dlls. But it may have only applied to Office.

>I removed the following two files from the Web site Bin directory:
>
>Interop.ADODB.dll
>Interop.CDO.dll
>
>...so I can run the Web site application pool in 64 bits.
>
>I would have assumed that a specific page on the Web site would no longer work as it has lines like this:
>
>

>        Dim loStream As ADODB.Stream = New ADODB.Stream
>
>        loStream.Mode = ADODB.ConnectModeEnum.adModeReadWrite
>        loStream.Type = ADODB.StreamTypeEnum.adTypeText
>        loStream.Open()
>
>        loStream.LoadFromFile(cFile)
>
>        oMessage.DataSource.OpenObject(loStream, "_Stream")
>
>        ' From
>        If Not RetrieveHeader(oMessage.From) Then
>            Return False
>        End If
>
>        cFrom = oMessage.From
>        cFromAddress = cAddress
>        cFromName = cName
>

>
>So, if the two 32 bit library files required for ADODB related commands to work are no longer in the Bin directory, how can this work? I did stop and start the Web site a few times.