>>F6 is standard as an alternative to Ctrl+Shift+B in C# . Not sure it's the same in VB..
>
>Not, it wouldn't do the same.
>
>>You can check them by looking in Options/Environment/Keyboard.
>
>I checked in there. I saw Build.Compile and an indication that Ctrl+F7. But, that does not work in any project.
>
>>Anything in the Output window when you use Ctrl+Shift+B ?
>
>No

OK. Just a thought:

Ctrl+Shift+B rebuilds the entire solution (not a specific project). If 'Build' isn't checked in the Configuration Manager for that project in the current configuration it might explain what you are seeing